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This limits the effectiveness of simple topical application

Liu JY, Lee KF, Sze CW, Tong Y, Tang SCW, Ng TB, et al

Additionally, the reduced plasma levels of brain-derived neurotrophic factor (BDNF) observed in BIPN patients may be associated with BTZ-mediated inhibition of platelet aggregation and activation, which in turn leads to decreased BDNF release and consequently impairs its neuroregenerative effects on peripheral nerves (Nishiwaki et al., 2020)